This conference aims to assemble leading geneticists, neuroscientists, and immunologists in an effort to explore important questions regarding the role of the immune system in the central nervous system during both health and disease. The goals of this meeting are the following: • Bring together different disciplines to investigate fundamental topics of neuroimmunology, such as immune control of CNS development, neuronal connectivity, myelination, circulation, as well as the role of the immune system in autoimmune and neurodegenerative diseases of the CNS. • Focus on the applications of emerging technologies to questions in neuroimmunology, such as -omics technologies, system biology and imaging. • Foster collaborations between immunologists, neuroscientists, and geneticists. • Encourage collaborations between academia and industry for the development of new avenues of intervention for multiple sclerosis and neurodegenerative diseases The anticipated outcomes of this meeting will include an increased awareness of the importance of the interplay between the immune system and the nervous system, the dissemination of the most up to date information in neuroimmunology, the application of new technologies to thus far intractable questions in neuroimmunology, and increased cross-discipline collaborations. This meeting will be held conjointly with the Keystone Meeting on Neurodegeneration; this combination will be beneficial in that it will emphasize the crossover between neurodegeneration and neuroimmunology. As neuroimmunology is a recently reinvigorated field this meeting will provide a critical opportunity to foster cross-disciplinary thinking.