Joint with: Immunometabolism in Tissue Homeostasis and Diseases
Trajectories to Heart Failure: Immunometabolic Mechanisms

Feb 10–13, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Joseph A. Hill, Geneviève Derumeaux, Chiara Giannarelli, and Gabriele G Schiattarella

  In Person
  On Demand
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Feb 10–13, 2025 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Joseph A. Hill, Geneviève Derumeaux, Chiara Giannarelli, and Gabriele G Schiattarella

Supported by:

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, February 10, 2025
Registration  
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer  
6:00–8:00 PM
 Longs Peak Foyer
Tuesday, February 11, 2025
Breakfast  
7:00–8:00 AM
 Quandary Peak
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Grays/Longs Peak
* Joseph A. Hill, University of Texas Southwestern Medical Center
* María Mittelbrunn, Molecular Biology Center, CSIC
Kathryn J Moore, New York University Medical Center
Immunometabolism in Cardiovascular Disease
Immunometabolism in Heart Failure and Vascular Diseases (Joint)  
9:00–11:30 AM
 Grays/Longs Peak
* Ronald J Vagnozzi, University of Colorado Anschutz Medical Campus
Chiara Giannarelli, NYU Grossman School of Medicine
Immune Mechanisms of Vascular Disease
Kathleen Martin, Yale School of Medicine
Novel Smooth Muscle Mechanisms in Transplant Vasculopathy
Xing Li Wang, Fosun Pharma
Challenges and Opportunities for Cardiovascular Drug Development
Esther Lutgens, Mayo Clinic
Co-Stimulatory Immune Checkpoints: Maintaining Immune Cell Homeostasis
Coffee Break  
9:30–9:50 AM
 Longs Peak Foyer
Award Recipient Acknowledgement  
9:50–9:55 AM
 Grays/Longs Peak
Poster Setup  
11:30–1:00 PM
 Quandary Peak
On Own for Lunch  
11:30–2:30 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peak
Panel Discussion 1: Dialogue with Scientists and Physician-Scientists in Industry  
2:30–4:30 PM
 Grays Peak
Rana Assaly, Cardiomedex
Alberto Guarnieri, Genentech
Douglas Hinerfeld, Alamar Biosciences
Caitlin Langford, Perspectum
Xiao-Jun Ma, Alamar Biosciences
Anne N Murphy, Cytokinetics, Inc.
Akshay Shekhar, Regeneron Pharmaceuticals
Kelly Yip, Perspectum Ltd.
James G Karras, Haya Therapeutics
Coleman Komishane, Monte Rosa Therapeutics
Xing Li Wang, Fosun Pharma
Jordan Shin, HAYA Therapeutics
* Adam E Mullick, Ionis Pharmaceuticals, Inc.
* James Priest, Tenaya Therapeutics
* Martin Borch Jensen, Gordian Biotechnology
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Ischemic HFrEF  
5:00–7:00 PM
 Grays Peak
* Patrick C.H. Hsieh, Academia Sinica
* Long-Sheng Song, Univ of Iowa
Biykem Bozkurt, Baylor College of Medicine
Ischemic HFrEF: Clinical Presentation and Unmet Needs
James Priest, Tenaya Therapeutics
Modulation of Fibrosis in HFrEF
Zoltan Arany, University of Pennsylvania
How do SGLT2 Inhibitors Benefit Heart Failure? (Hint: it’s not SGLT2)
Lena Ho, Duke-NUS Medical School
Short Talk: Respiratory Chain Supercomplexes Protect Against Ischemic Heart Failure
Gregory Wyant, MGH
Short Talk: Plasmalogen Control of Peroxisome Degradation Confers Ischemic Protection
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peak
Women in Science Networking Event  
7:05–8:05 PM
 Quandary Peak Foyer
* María Mittelbrunn, Molecular Biology Center, CSIC
Session Chair
* Gemma A Figtree, Kolling Institute, University of Sydney
Session Chair
* Kathryn E. Wellen, University of Pennsylvania
Session Chair
* Chiara Giannarelli, NYU Grossman School of Medicine
Session Chair
* Esther Lutgens, Mayo Clinic
Session Chair
* Pilar Alcaide, Tufts University School of Medicine
Session Chair
* Marlies Meisel, University of Pittsburgh
Session Chair
Poster Session 1  
7:30–10:00 PM
 Quandary Peak
Wednesday, February 12, 2025
Breakfast  
7:00–8:00 AM
 Quandary Peak
Cardiometabolic HFpEF  
8:00–11:00 AM
 Grays Peak
* Karen A Ocorr, SBP Medical Discovery Institute
Sanjiv Shah, Northwestern University
HFpEF: Clinical Presentations and Unmet Needs
Gabriele G Schiattarella, Charité University Medical Center
Metabolic Regulation of HFpEF
Virginia Hahn, Johns Hopkins University
Single Cell Analysis of HFpEF
Ling Yang, University of Iowa
Short Talk: Lysosome Maintains Cardiac Immuno-metabolic Homeostasis in HFpEF
Ulrich Kintscher, Charité-Universitätsmedizin Berlin
Short Talk: Endothelial Deletion of Adipose Triglyceride Lipase Protects Against Heart Failure with Preserved Ejection Fraction
Martin Borch Jensen, Gordian Biotechnology
Short Talk: Novel in Vivo Screen System to Identify Therapeutic Targets in Heart Failure with Preserved Ejection Fraction
Giuseppe D Norata, University of Milan
Short Talk: PCSK9 at the Crossroad of Cardiac Metabolic Reprogramming During Hfpef
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup  
11:00–1:00 PM
 Quandary Peak
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peak
Career Roundtable (Joint)  
3:00–4:30 PM
 Grays Peak
James Priest, Tenaya Therapeutics
Senior Director of Cardiovascular Genetics
Maria Rescigno, Humanitas University
Professor, Group Leader, and Deputy Scientific Director
Meng-Ju Wu, University of Massachusetts Chan Medical School
Assistant Professor
Anne N Murphy, Cytokinetics, Inc.
Vice President, Scientific Affairs
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Immunometabolic Exposome in HFpEF (Joint)  
5:00–7:00 PM
 Grays/Longs Peak
* Matthew J Feinstein, Northwestern University
Edward Thorp, Northwestern University
Myeloid Metabolism in the Amplification and Resolution of Cardiac Inflammation
Geneviève Derumeaux, INSERM U955, Université Paris-Est Creteil
HFpEF: Obesity-Induced Immuno-Inflammation
Pilar Alcaide, Tufts University School of Medicine
Immune Crosstalk in HFpEF
Joseph A. Hill, University of Texas Southwestern Medical Center
Immuno-Metabolic Mechanisms of HFpEF
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peak
Poster Session 2  
7:30–10:00 PM
 Quandary Peak
Thursday, February 13, 2025
Breakfast  
7:00–8:00 AM
 Quandary Peak
Afterload-Induced HFrEF  
8:00–11:00 AM
 Grays Peak
* Vlad Zaha, University of Texas Southwestern Medical Center
Peter Liu, University of Ottawa Heart Institute
Coordination between Immunity, Metabolism and Microvasculature in Heart Failure: Now Reaching the Brain
Anthony Rosenzweig, University of Michigan
Age-related Pathways in Heart Failure - Not Just for the Old
Fady Malik, Cytokinetics Inc.
Sarcomere-Targeted Drugs
Gemma A Figtree, Kolling Institute, University of Sydney
Short Talk: Advanced Immune and Lipidomic Profiling in Humans and Chimpanzees to Unravel Novel Factors in CT-Image Defined Coronary Artery Disease Susceptibility and Resilience
Niranjana Natarajan, Universitty of Pittsburgh
Short Talk: Spatial Transcriptomic Profiling of Macrophage–Fibroblast Dynamics in Heart Failure
Justin H Berger, Washington University School of Medicine
Short Talk: SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice
Hyun Kook, Chonnam National University
Short Talk: Loss of p300/CBP-Associated Factor Aggravates Cardiac Remodeling Via Regulation Of Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Acetylation
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch  
11:00–2:30 PM
Panel Discussion 2: Dialogue with Journal Editors (Joint)  
3:00–4:30 PM
 Grays Peak
Joseph A. Hill, University of Texas Southwestern Medical Center
*Session Chair, Editor in Chief, Circulation
Gabriele G Schiattarella, Charité University Medical Center
*Session Chair, Associate Editor, Circulation
Vesna Todorovic, Springer Nature
Chief Editor, Nature Cardiovascular Research
Bruce D. Koppelman, Cell Press
Scientific Editor, Immunity
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
HFrEF: Other Mechanisms  
5:00–6:45 PM
 Grays Peak
* Ryan L Boudreau, University of Iowa
Stavros G. Drakos, University of Utah
Metabolism and Myocardial Recovery in Heart Failure
Daniela Carnevale, University La Sapienza in Rome
Neuroimmune Mechanisms of Cardiac Remodeling
Adam E Mullick, Ionis Pharmaceuticals, Inc.
RNA Therapeutic Approaches for Heart Failure
Luca Scorrano, University of Padova
Short Talk: Coordination Between Mitochondrial Dynamics and Autophagy in Heart Failure
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Grays Peak
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peak
Entertainment  
8:00–9:00 PM
 Longs Peak
Cash Bar  
8:00–9:00 PM
 Quandary Peak
Friday, February 14, 2025
Departure  
12:00–11:59 PM

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